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Replication

The DNA molecular structure resembles a zip fastener, where each tooth can be any of four molecular bases.  The bases G-C and A-T are each small organic molecules that at one point are covalently bound to a triphosphate (containing three phosphorous atoms) and a sugar group that binds them in a ribbon.  At their free end Guanine is attracted to Cytosine, with triple hydrogen bonds, and Adenine is attracted to Thymine, with double hydrogen bonds. 

In the following notation: black = Carbon;  blue = Nitrogen;  red = Oxygen; white = Hydrogen.   Bars joining them indicate a covalent bond, an electron shared between the atoms.  A double bar indicates two shared electrons.   

 

Cytosine  Cytosine (C4H5N3O) has a shape that attracts (fits)  Guanine Guanine (C5H5N5O) 


but not  Thymine Thymine (C5H6N2O2)  or  Adenine Adenine (C5H5N5), that attract (fit) each other.

 

Each of these bases is bound to a ribbon of  sugar molecules and at its other end lightly bonds to a matching base on the other half of the 'zipper' such that when it is 'unzipped' each attracts its opposite number (like magnets attracting the opposite pole) thus recreating a new matching half in the same sequence.

 

DNA replication.
DNA replication. 

 

This unzipping and reforming is called self-replication. It is going on continuously in all living things as new cells are created to replace those that die. In an adult human around three quarters of a million of our cells divide every second.  This cell division is the process we call organic life and may continue (usually briefly) after we are legally (brain) dead.

Other chemical mechanisms within the cell translate the genetic information stored in the DNA sequence to manufacture the proteins from which new cells are built and differentiate themselves, organising to become our various organs and to thus arrange themselves to form a human; and not a gorilla or a crocodile or a kola or a rose or a cabbage. The human genome project had now identified 32,185 human genes.

Accurate reproduction is very important to the viability of an organism.  Just as: 'WOLF' does not have the same meaning as 'FOWL' the location and order of sequence G-A-T-C within a particular DNA string (chromosome) will result in a different outcome to the sequence C-A-G-T .   And this difference will influence cell structure and purpose:   'The wolf eats the fowl' has a totally different meaning to: 'The fowl eats the wolf'.

This method of storing and reproducing instructions and data is twice as efficient as the binary method we presently use in electronic devices.  For example the binary processor in your computer or reading device requires each character in in each word in this sentence to be encoded in two bytes (each of 8 characters or bits).  In other words 16 ones and zeros are required for every character on this page (eg 'a' = 0000000001100001) and a similar number for each pixel in a simple colour image.  But DNA can encode the same information (sufficient for every unique character and symbol in every language in the world) in just eight characters.

There are a fraction over 3 billion characters in the human genome (3,079,843,747 base pairs).  In computer terms this is equivalent to about three quarters of a gigabyte of information storage. The same data is stored in the nucleus of each of our cells.  This is in nuclear DNA, before taking into account separate, but smaller, storage in each of the mitochondria (see below). 

A 'gig' isn't much you might say (less than $1's worth) but the actual data storage density is in excess of anything offered by our present electronic technology.  Cells are a lot smaller than the chip in a memory stick - there around a billion cells per cubic centimetre in hard tissue.

This also points to another reality.  Had not this replication chemistry been available, and the conditions for the reactions been just right, life could not have occurred in its earthly form. 

Life relying on another replication method that was say binary would be at a disadvantage and would have to use different replication mechanisms.  If there was a chemistry, at different temperatures and chemical concentrations, allowing say six base pairs it would be different again.  We and our cousins (the other animals, plants and other organisms) that are all descended from the original replicating cell (LUCA - see above) are here because the conditions on Earth were and are just right for our kind of life to prosper.

Elsewhere in the universe it may be different.

 

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Israel

 

 

 

 

 

2024 Addendum

 

It's shocking that another Addendum to this article is necessary.

Yet, we are no nearer to a peaceful resolution like the, internationally called for, 'Two state solution', or some workable version thereof.

Indeed, the situation, particularly for Palestinians, has gone from bad to worse.

At the same time, Israeli losses are mounting as the war drags on.  Yet, Hamas remains undefeated and Bibi remains recalcitrant.

Comments:

 On Wed, 4 Sep 2024, at 1:23 PM, Barry Cross wrote:
> There seems to be no resolution to the problem of the disputed land of Israel. You consider Gaza to have been put under siege, but I wonder if that and the other Israeli acts you mention are themselves responses to a response by them of being under siege, or at least being seriously threatened, by hostile forces who do not recognise the legitimacy of the state of Israel? Hamas’s claim and stated intention of establishing a Palestinian state “from the river to the sea” and periodic acts of aggression need to be taken into account I suggest, when judging the actions of the Israeli’s. In addition, there is the menace coming from Iranian proxies in Southern Lebanon and Yemen, and from Iran itself.
>
> Whatever the merits of the respective claims to the contended territory might be, it seems reasonable to accept that Israeli’s to consider they are a constant threat to their very survival. Naturally, this must influence their actions, particularly in response to the many acts of aggression they have been subjected to over many decades. By way of contrast, how lucky are we!
>
> These are my off the cuff comments for what they are worth.
>
> Regards
> Barry Cross
>
> Sent from my iPhone

 

 

 

2023 Addendum

 

It's a decade since this visit to Israel in September 2014.

From July until just a month before we arrived, Israeli troops had been conducting an 'operation' against Hamas in the Gaza strip, in the course of which 469 Israeli soldiers lost their lives.  The country was still reeling. 

17,200 Garzan homes were totally destroyed and three times that number were seriously damaged.  An estimated 2,000 (who keeps count) civilians died in the destruction.  'Bibi' Netanyahu, who had ordered the Operation, declared it a victory.

This time it's on a grander scale: a 'War', and Bibi has vowed to wipe-out Hamas.

Pundits have been moved to speculate on the Hamas strategy, that was obviously premeditated. In addition to taking hostages, it involving sickening brutality against obvious innocents, with many of the worst images made and published by themselves. 

It seemed to be deliberate provocation, with a highly predictable outcome.

Martyrdom?  

Historically, Hamas have done Bibi no harm.  See: 'For years, Netanyahu propped up Hamas. Now it’s blown up in our faces' in the Israel Times.

Thinking about our visit, I've been moved to wonder how many of today's terrorists were children a decade ago?  How many saw their loved ones: buried alive; blown apart; maimed for life; then dismissed by Bibi as: 'collateral damage'? 

And how many of the children, now stumbling in the rubble, will, in their turn, become terrorists against the hated oppressor across the barrier?

Is Bibi's present purge a good strategy for assuring future harmony?

I commend my decade old analysis to you: A Brief Modern History and Is there a solution?

Comments: 
Since posting the above I've been sent the following article, implicating religious belief, with which I substantially agree, save for its disregarding the Jewish fundamentalists'/extremists' complicity; amplifying the present horrors: The Bright Line Between Good and Evil 

Another reader has provided a link to a perspective similar to my own by Australian 'Elder Statesman' John MenadueHamas, Gaza and the continuing Zionist project.  His Pearls and Irritations site provides a number of articles relating to the current Gaza situation. Worth a read.

The Economist has since reported and unusual spate of short-selling immediately preceding the attacks: Who made millions trading the October 7th attacks?  

Money-making by someone in the know? If so, it's beyond evil.

 

 

A Little Background

The land between the Jordan river and the Mediterranean Sea, known as Palestine, is one of the most fought over in human history.  Anthropologists believe that the first humans to leave Africa lived in and around this region and that all non-African humans are related to these common ancestors who lived perhaps 70,000 years ago.  At first glance this interest seems odd, because as bits of territory go it's nothing special.  These days it's mostly desert and semi-desert.  Somewhere back-o-Bourke might look similar, if a bit redder. 

Yet since humans have kept written records, Egyptians, Canaanites, Philistines, Ancient Israelites, Assyrians, Babylonians, Persians, Greeks, Romans, Byzantines, early Muslims, Christian Crusaders, Ottomans (and other later Muslims), British and Zionists, have all fought to control this land.  This has sometimes been for strategic reasons alone but often partly for affairs of the heart, because this land is steeped in history and myth. 

Read more: Israel

Fiction, Recollections & News

His life in a can

A Short Story

 

 

"She’s put out a beer for me!   That’s so thoughtful!" 

He feels shamed, just when he was thinking she takes him for granted.

He’s been slaving away out here all morning in the sweltering heat, cutting-back this enormous bloody bougainvillea that she keeps nagging him about.  It’s the Council's green waste pick-up tomorrow and he’s taken the day off, from the monotony of his daily commute, to a job that he has long since mastered, to get this done.  

He’s bleeding where the thorns have torn at his shirtless torso.  His sweat makes pink runnels in the grey dust that is thick on his office-pale skin.  The scratches sting, as the salty rivulets reach them, and he’s not sure that he hasn’t had too much sun.  He knows he’ll be sore in the office tomorrow.

Read more: His life in a can

Opinions and Philosophy

Medical fun and games

 

 

 

 

We all die of something.

After 70 it's less likely to be as a result of risky behaviour or suicide and more likely to be heart disease followed by a stroke or cancer. Unfortunately as we age, like a horse in a race coming up from behind, dementia begins to take a larger toll and pulmonary disease sees off many of the remainder. Heart failure is probably the least troublesome choice, if you had one, or suicide.

In 2020 COVID-19 has become a significant killer overseas but in Australia less than a thousand died and the risk from influenza, pneumonia and lower respiratory conditions had also fallen as there was less respiratory infection due to pandemic precautions and increased influenza immunisation. So overall, in Australia in 2020, deaths were below the annual norm.  Yet 2021 will bring a new story and we've already had a new COVID-19 hotspot closing borders again right before Christmas*.

So what will kill me?

Some years back, in October 2016, at the age of 71, my aorta began to show it's age and I dropped into the repair shop where a new heart valve - a pericardial bio-prosthesis - was fitted. See The Meaning of Death elsewhere on this website. This has reduced my chances of heart failure so now I need to fear cancer; and later, dementia.  

More fun and games.

Read more: Medical fun and games

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