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Replication

The DNA molecular structure resembles a zip fastener, where each tooth can be any of four molecular bases.  The bases G-C and A-T are each small organic molecules that at one point are covalently bound to a triphosphate (containing three phosphorous atoms) and a sugar group that binds them in a ribbon.  At their free end Guanine is attracted to Cytosine, with triple hydrogen bonds, and Adenine is attracted to Thymine, with double hydrogen bonds. 

In the following notation: black = Carbon;  blue = Nitrogen;  red = Oxygen; white = Hydrogen.   Bars joining them indicate a covalent bond, an electron shared between the atoms.  A double bar indicates two shared electrons.   

 

Cytosine  Cytosine (C4H5N3O) has a shape that attracts (fits)  Guanine Guanine (C5H5N5O) 


but not  Thymine Thymine (C5H6N2O2)  or  Adenine Adenine (C5H5N5), that attract (fit) each other.

 

Each of these bases is bound to a ribbon of  sugar molecules and at its other end lightly bonds to a matching base on the other half of the 'zipper' such that when it is 'unzipped' each attracts its opposite number (like magnets attracting the opposite pole) thus recreating a new matching half in the same sequence.

 

DNA replication.
DNA replication. 

 

This unzipping and reforming is called self-replication. It is going on continuously in all living things as new cells are created to replace those that die. In an adult human around three quarters of a million of our cells divide every second.  This cell division is the process we call organic life and may continue (usually briefly) after we are legally (brain) dead.

Other chemical mechanisms within the cell translate the genetic information stored in the DNA sequence to manufacture the proteins from which new cells are built and differentiate themselves, organising to become our various organs and to thus arrange themselves to form a human; and not a gorilla or a crocodile or a kola or a rose or a cabbage. The human genome project had now identified 32,185 human genes.

Accurate reproduction is very important to the viability of an organism.  Just as: 'WOLF' does not have the same meaning as 'FOWL' the location and order of sequence G-A-T-C within a particular DNA string (chromosome) will result in a different outcome to the sequence C-A-G-T .   And this difference will influence cell structure and purpose:   'The wolf eats the fowl' has a totally different meaning to: 'The fowl eats the wolf'.

This method of storing and reproducing instructions and data is twice as efficient as the binary method we presently use in electronic devices.  For example the binary processor in your computer or reading device requires each character in in each word in this sentence to be encoded in two bytes (each of 8 characters or bits).  In other words 16 ones and zeros are required for every character on this page (eg 'a' = 0000000001100001) and a similar number for each pixel in a simple colour image.  But DNA can encode the same information (sufficient for every unique character and symbol in every language in the world) in just eight characters.

There are a fraction over 3 billion characters in the human genome (3,079,843,747 base pairs).  In computer terms this is equivalent to about three quarters of a gigabyte of information storage. The same data is stored in the nucleus of each of our cells.  This is in nuclear DNA, before taking into account separate, but smaller, storage in each of the mitochondria (see below). 

A 'gig' isn't much you might say (less than $1's worth) but the actual data storage density is in excess of anything offered by our present electronic technology.  Cells are a lot smaller than the chip in a memory stick - there around a billion cells per cubic centimetre in hard tissue.

This also points to another reality.  Had not this replication chemistry been available, and the conditions for the reactions been just right, life could not have occurred in its earthly form. 

Life relying on another replication method that was say binary would be at a disadvantage and would have to use different replication mechanisms.  If there was a chemistry, at different temperatures and chemical concentrations, allowing say six base pairs it would be different again.  We and our cousins (the other animals, plants and other organisms) that are all descended from the original replicating cell (LUCA - see above) are here because the conditions on Earth were and are just right for our kind of life to prosper.

Elsewhere in the universe it may be different.

 

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Travel

Canada and the United States - Part1

 

 

In July and August 2023 Wendy and I travelled to the United States again after a six-year gap. Back in 2007 we visited the east coast and west coast and in 2017 we visited 'the middle bits', travelling down from Chicago via Memphis to New Orleans then west across Texas, New Mexico, Nevada and California on our way home.

So, this time we went north from Los Angeles to Seattle, Washington, and then into Canada. From Vancouver we travelled by car, over the Rockies, then flew east to Toronto where we hired a car to travel to Ottawa and Montreal. Our next flight was all the way down to Miami, Florida, then to Fort Lauderdale, where we joined a western Caribbean cruise.  At the end of the cruise, we flew all the way back up to Boston.

Seems crazy but that was the most economical option.  From Boston we hired another car to drive, down the coast, to New York. After New York we flew to Salt Lake City then on to Los Angeles, before returning to OZ.

As usual, save for a couple of hotels and the cars, Wendy did all the booking.

Breakfast in the Qantas lounge on our way to Seattle
Wendy likes to use two devices at once

Read more: Canada and the United States - Part1

Fiction, Recollections & News

Egyptian Mummies

 

 

 

 

Next to Dinosaurs mummies are the museum objects most fascinating to children of all ages. 

At the British Museum in London crowds squeeze between show cases to see them.  At the Egyptian Museum in Cairo they are, or were when we visited in October 2010 just prior to the Arab Spring, by far the most popular exhibits (follow this link to see my travel notes). Almost every large natural history museum in the world has one or two mummies; or at the very least a sarcophagus in which one was once entombed.

In the 19th century there was something of a 'mummy rush' in Egypt.  Wealthy young European men on their Grand Tour, ostensibly discovering the roots of Western Civilisation, became fascinated by all things 'Oriental'.  They would pay an Egyptian fortune for a mummy or sarcophagus.  The mummy trade quickly became a lucrative commercial opportunity for enterprising Egyptian grave-robbers.  

Read more: Egyptian Mummies

Opinions and Philosophy

The reputation of nuclear power

 

 

One night of at the end of March in 1979 we went to a party in Queens.  Brenda, my first wife, is an artist and was painting and studying in New York.  Our friends included many of the younger artists working in New York at the time.  That day it had just been announced that there was a possible meltdown at a nuclear reactor at a place called a Three Mile Island , near Harrisburg Pennsylvania. 

I was amazed that some people at the party were excitedly imagining that the scenario in the just released film ‘The China Syndrome’  was about to be realised; and thousands of people would be killed. 

Read more: The reputation of nuclear power

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