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Replication

The DNA molecular structure resembles a zip fastener, where each tooth can be any of four molecular bases.  The bases G-C and A-T are each small organic molecules that at one point are covalently bound to a triphosphate (containing three phosphorous atoms) and a sugar group that binds them in a ribbon.  At their free end Guanine is attracted to Cytosine, with triple hydrogen bonds, and Adenine is attracted to Thymine, with double hydrogen bonds. 

In the following notation: black = Carbon;  blue = Nitrogen;  red = Oxygen; white = Hydrogen.   Bars joining them indicate a covalent bond, an electron shared between the atoms.  A double bar indicates two shared electrons.   

 

Cytosine  Cytosine (C4H5N3O) has a shape that attracts (fits)  Guanine Guanine (C5H5N5O) 


but not  Thymine Thymine (C5H6N2O2)  or  Adenine Adenine (C5H5N5), that attract (fit) each other.

 

Each of these bases is bound to a ribbon of  sugar molecules and at its other end lightly bonds to a matching base on the other half of the 'zipper' such that when it is 'unzipped' each attracts its opposite number (like magnets attracting the opposite pole) thus recreating a new matching half in the same sequence.

 

DNA replication.
DNA replication. 

 

This unzipping and reforming is called self-replication. It is going on continuously in all living things as new cells are created to replace those that die. In an adult human around three quarters of a million of our cells divide every second.  This cell division is the process we call organic life and may continue (usually briefly) after we are legally (brain) dead.

Other chemical mechanisms within the cell translate the genetic information stored in the DNA sequence to manufacture the proteins from which new cells are built and differentiate themselves, organising to become our various organs and to thus arrange themselves to form a human; and not a gorilla or a crocodile or a kola or a rose or a cabbage. The human genome project had now identified 32,185 human genes.

Accurate reproduction is very important to the viability of an organism.  Just as: 'WOLF' does not have the same meaning as 'FOWL' the location and order of sequence G-A-T-C within a particular DNA string (chromosome) will result in a different outcome to the sequence C-A-G-T .   And this difference will influence cell structure and purpose:   'The wolf eats the fowl' has a totally different meaning to: 'The fowl eats the wolf'.

This method of storing and reproducing instructions and data is twice as efficient as the binary method we presently use in electronic devices.  For example the binary processor in your computer or reading device requires each character in in each word in this sentence to be encoded in two bytes (each of 8 characters or bits).  In other words 16 ones and zeros are required for every character on this page (eg 'a' = 0000000001100001) and a similar number for each pixel in a simple colour image.  But DNA can encode the same information (sufficient for every unique character and symbol in every language in the world) in just eight characters.

There are a fraction over 3 billion characters in the human genome (3,079,843,747 base pairs).  In computer terms this is equivalent to about three quarters of a gigabyte of information storage. The same data is stored in the nucleus of each of our cells.  This is in nuclear DNA, before taking into account separate, but smaller, storage in each of the mitochondria (see below). 

A 'gig' isn't much you might say (less than $1's worth) but the actual data storage density is in excess of anything offered by our present electronic technology.  Cells are a lot smaller than the chip in a memory stick - there around a billion cells per cubic centimetre in hard tissue.

This also points to another reality.  Had not this replication chemistry been available, and the conditions for the reactions been just right, life could not have occurred in its earthly form. 

Life relying on another replication method that was say binary would be at a disadvantage and would have to use different replication mechanisms.  If there was a chemistry, at different temperatures and chemical concentrations, allowing say six base pairs it would be different again.  We and our cousins (the other animals, plants and other organisms) that are all descended from the original replicating cell (LUCA - see above) are here because the conditions on Earth were and are just right for our kind of life to prosper.

Elsewhere in the universe it may be different.

 

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Travel

Turkey

 

 

 

 

In August 2019 we returned to Turkey, after fourteen years, for a more encompassing holiday in the part that's variously called Western Asia or the Middle East.  There were iconic tourist places we had not seen so with a combination of flights and a rental car we hopped about the map in this very large country. 

We began, as one does, in Istanbul. 

Read more: Turkey

Fiction, Recollections & News

The McKie Family

 

 

 

 

Introduction

 

 

This is the story of the McKie family down a path through the gardens of the past that led to where I'm standing.  Other paths converged and merged as the McKies met and wed and bred.  Where possible I've glimpsed backwards up those paths as far as records would allow. 

The setting is Newcastle upon Tyne in northeast England and my path winds through a time when the gardens there flowered with exotic blooms and their seeds and nectar changed the entire world.  This was the blossoming of the late industrial and early scientific revolution and it flowered most brilliantly in Newcastle.

I've been to trace a couple of lines of ancestry back six generations to around the turn of the 19th century. Six generations ago, around the turn of the century, lived sixty-four individuals who each contributed a little less 1.6% of their genome to me, half of them on my mother's side and half on my father's.  Yet I can't name half a dozen of them.  But I do know one was called McKie.  So, this is about his descendants; and the path they took; and some things a few of them contributed to Newcastle's fortunes; and who they met on the way.

In six generations, unless there is duplication due to copulating cousins, we all have 126 ancestors.  Over half of mine remain obscure to me but I know the majority had one thing in common, they lived in or around Newcastle upon Tyne.  Thus, they contributed to the prosperity, fertility and skill of that blossoming town during the century and a half when the garden there was at its most fecund. So, it's also a tale of one city.

My mother's family is the subject of a separate article on this website. 

 

Read more: The McKie Family

Opinions and Philosophy

Losing my religion

 

 

 

 

In order to be elected every President of the United States must be a Christian.  Yet the present incumbent matches his predecessor in the ambiguities around his faith.  According to The Holloverse, President Trump is reported to have been:  'a Catholic, a member of the Dutch Reformed Church, a Presbyterian and he married his third wife in an Episcopalian church.' 

He is quoted as saying: "I’ve had a good relationship with the church over the years. I think religion is a wonderful thing. I think my religion is a wonderful religion..."

And whatever it is, it's the greatest.

Not like those Muslims: "There‘s a lot of hatred there that’s someplace. Now I don‘t know if that’s from the Koran. I don‘t know if that’s from someplace else but there‘s tremendous hatred out there that I’ve never seen anything like it."

And, as we've been told repeatedly during the recent campaign, both of President Obama's fathers were, at least nominally, Muslim. Is he a real Christian?  He's done a bit of church hopping himself.

In 2009 one time United States President Jimmy Carter went out on a limb in an article titled: 'Losing my religion for equality' explaining why he had severed his ties with the Southern Baptist Convention after six decades, incensed by fundamentalist Christian teaching on the role of women in society

I had not seen this article at the time but it recently reappeared on Facebook and a friend sent me this link: Losing my religion for equality...

Read more: Losing my religion

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