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Viruses

Viruses have been around since life began but they are 'of life', they are not technically 'alive' because they cannot themselves reproduce. They are extremely small - about 70 microns in diametre - and until the invention of electron microscopes in the 1930's their existance had only been inferred. 

To create copies of themselves they need a host cell with the necessary reproductive mechanisms. Over the millennia viruses have evolved the necessary mechanisms to penetrate cells, much like spermatozoa, and inject their DNA or RNA and capture the host's replication mechanisms so that the infected cell begins manufacturing thousands of virion (virus particle) clones of the invader. These then capture other nearby cells in the host animal or plant; or in similar bacteria.  Huge numbers of infected cells are usually destroyed in the process, sometimes killing the plant or animal.

 

c0487121 cell infected with covid 19 coronavirus particles sem web

Coronavirus particles (yellow) on the surface of a dying cell (that produced them)
Niaid/National Institutes of Health/Science Photo Library (from 
https://www.newscientist.com)

 

But animals plants and bacteria have become familiar with this threat and have in turn evolved means of dealing with or living with viruses to the extent that some are exploited for the benefit of the host.

In turn viruses evolve new strategies to perpetuate their reproduction. Thus new viruses arise from time to time, sometimes jumping from one species to another when an opportunity arises.

Many animals, including humans, have an immune system that has a memory of harmful viruses and means of neutralising them. Thus, once the animal has been infected and survived, the chances of reinfection are reduced.  Vaccines work by presenting our immune system with a harmless sample that allows it to recognise a particular harmful virus.

Since I first wrote this article the World has suffered a new viral pandemic.  It is a novel corona virus for which we have no established immunity and there is no vaccine.  At the end of June 2020 the Covi-19 virus has already killed half a million people.

It is estimated that this virus will no longer find sufficient vulnerable hosts to spread further after infecting around 70% of the populations in which it is spreading.  It has a case fatality rate of just under 1%, that is, of those who catch it just under one in a hundred die.  

Quarantine restrictions are in place in many countries to protect relatively uninfected areas, with local measures to eliminate 'hot spots'.  But the majority of the world's population, in excess of five billion, are in countries in which it is presently spreading.

Unless a vaccine is available soon it seems inevitable that many millions more will be killed.  The economic consequences are also dire.

 

 

 

 

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Travel

Bridge over the River Kwai

 

 

In 1957-58 the film ‘The Bridge on the River Kwai‘ was ground breaking.  It was remarkable for being mainly shot on location (in Ceylon not Thailand) rather than in a studio and for involving the construction and demolition of a real, fully functioning rail bridge.   It's still regarded by many as one of the finest movies ever made. 

One of the things a tourist to Bangkok is encouraged to do is to take a day trip to the actual bridge.

Read more: Bridge over the River Kwai

Fiction, Recollections & News

The new James Bond

 

 

It was raining in the mountains on Easter Saturday.

We'd decided to take a couple of days break in the Blue Mountains and do some walking. But on Saturday it poured.  In the morning we walked two kilometres from Katoomba to more up-market and trendy Leura for morning coffee and got very wet.

After a train journey to Mount Victoria and back to dry out and then lunch in the Irish Pub, with a Cider and Guinness, we decided against another soaking and explored the Katoomba antique stores and bookshops instead.  In one I found and bought an unread James Bond book.  But not by the real Ian Fleming. 

Ian Fleming died in 1964 at the young age of fifty-six and I'd read all his so I knew 'Devil May Care' was new.  This one is by Sebastian Faulks, known for his novel Birdsong, 'writing as Ian Fleming' in 2008.

Read more: The new James Bond

Opinions and Philosophy

A Dismal Science

 

 

Thomas Carlyle coined this epithet in 1839 while criticising  Malthus, who warned of what subsequently happened, exploding population.

According to Carlyle his economic theories: "are indeed sufficiently mournful. Dreary, stolid, dismal, without hope for this world or the next" and in 1894 he described economics as: 'quite abject and distressing... dismal science... led by the sacred cause of Black Emancipation.'  The label has stuck ever since.

This 'dismal' reputation has not been helped by repeated economic recessions and a Great Depression, together with continuously erroneous forecasts and contradictory solutions fuelled by opposing theories.  

This article reviews some of those competing paradigms and their effect on the economic progress of Australia.

Read more: A Dismal Science

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