Who is Online

We have 21 guests and no members online

Gene Mapping

Genes are just patterns of chemical molecules that are held within the replicating DNA mechanism.  The way they are encoded onto DNA can be likened to any other mechanism for copying and recording data: a DVD or even a vinyl record or the memory in this computer.  As a result they can be altered or damaged from time to time and some of these variations are successfully copied into subsequent offspring.  If they are particularly advantageous to survival and reproduction these changes, or mutations, rapidly spread throughout the species, so that over tens of thousands of years, individuals successful in one environmental niche are so different from those successful in another that a new species has formed (followed by a new genus, family, order, and so on). 

This process of periodic differentiation has been likened to the branching of a tree but because of the activity of bacteria and viruses and residual DNA that may be reactivated as well as limited cross-species reproduction  (for example later Humans and Neanderthal) it is no longer believed to be quite that simple.

DNA encodes the instructions for creating each cellular colony, defining each species, and each individual within a species. DNA changes over time in such away that each change is a development on previous generations. So it is possible to trace DNA ancestry back through generations of a particular species over time.  For example, DNA studies are increasingly shedding light on the questions around human origins. 

Most animals, including humans, carry two types of DNA.  Our main genome is carried by the chromosomes in the nucleus of each of our cells. This comes from both our parents. The secondary genome, mtDNA, is carried by bacteria-like organelles within each of our cells, that convert sugars for cell energy, called mitochondria. These are all cloned (reproduced by asexual division) from the mitochondria that were within the original egg cell provided by our mother.

Cells may contain from one mitochondrion to several thousand mitochondria depending on species and cell differentiation.  As a result this is the predominant DNA found in a cellular sample.

So our mtDNA comes only from our mother; in turn from her mother; and so on and mtDNA allows us to map the female ancestral line.  This original egg cell was fertilised by a sperm from our father (sperm do not contribute their mitochondria). Once fertilised, the egg cell then divided repeatedly, differentiating in accordance with the coding instructions in our DNA, into the many cells that form the cellular colony that became 'us'.

Males are differentiated from females by a Y chromosome in place of one X. So sons can only inherit this from their father (like their family name in our culture) and periodic mutations in the DNA of the Y chromosome allow the (actual) male ancestral line to be traced back.

As a result of this work we now know that humans on the planet are all descended from a single group that left Africa less than 70 thousand years ago. 

Recent DNA analysis shows that early humans sometimes interbred with the Neanderthal; a separate hominid subspecies that left Africa much earlier and settled in the Middle East and Europe over quarter of a million years ago.

It's amazing to think that we have only understood it within my lifetime. Now the ancient view that people grow from a seed, provided by their father, and gain the spark of life at 'conception' from a god is totally debunked. So throw away all those ancient texts.

 

No comments

Travel

Istanbul

 

 

Or coming down to earth...

 

When I was a boy, Turkey was mysterious and exotic place to me. They were not Christians there; they ate strange food; and wore strange clothes. There was something called a ‘bazaar’ where white women were kidnapped and sold into white slavery. Bob Hope and Bing Crosby, or was it Errol Flynn, got into all sorts of trouble there with blood thirsty men with curved swords. There was a song on the radio that reminded me over and over again that ‘It’s Istanbul not Constantinople Now’, sung by The Four Lads, possibly the first ‘boy band’.

 

Read more: Istanbul

Fiction, Recollections & News

The Atomic Bomb according to ChatGPT

 

Introduction:

The other day, my regular interlocutors at our local shopping centre regaled me with a new question: "What is AI?" And that turned into a discussion about ChatGPT.

I had to confess that I'd never used it. So, I thought I would 'kill two birds with one stone' and ask ChatGPT, for material for an article for my website.

Since watching the movie Oppenheimer, reviewed elsewhere on this website, I've found myself, from time-to-time, musing about the development of the atomic bomb and it's profound impact on the modern world. 

Nuclear energy has provided a backdrop to my entire life. The first "atomic bombs" were dropped on Japan the month before I was born. Thus, the potential of nuclear energy was first revealed in an horrendous demonstration of mankind's greatest power since the harnessing of fire.

Very soon the atomic reactors, that had been necessary to accumulate sufficient plutonium for the first bombs, were adapted to peaceful use.  Yet, they forever carried the stigma of over a hundred thousand of innocent lives lost, many of them young children, at Hiroshima and Nagasaki.

The fear of world devastation followed, as the US and USSR faced-off with ever more powerful weapons of mass destruction.

The stigma and fear has been unfortunate, because, had we more enthusiastically embraced our new scientific knowledge and capabilities to harness this alternative to fire, the threat to the atmosphere now posed by an orgy of burning might have been mitigated.

Method:

So, for this article on the 'atomic bomb', I asked ChatGPT six questions about:

  1. The Manhattan Project; 
  2. Leo Szilard (the father of the nuclear chain reaction);
  3. Tube Alloys (the British bomb project);
  4. the Hanford site (plutonium production);
  5. uranium enrichment (diffusion and centrifugal); and
  6. the Soviet bomb project.

As ChatGPT takes around 20 seconds to write 1000 words and gives a remarkably different result each time, I asked it each question several times and chose selectively from the results.

This is what ChatGPT told me about 'the bomb':

Read more: The Atomic Bomb according to ChatGPT

Opinions and Philosophy

The Fukushima Nuclear Crisis

 

 

Japan has 55 nuclear reactors at 19 sites.  Two more are under construction and another twelve are in the advanced planning stage.  Net Generating capacity is around 50 GW providing around 30% of the country's electricity (more here).  

As a result of Japan’s largest earthquake in history on March 11 and subsequent tsunami all reactors shut down automatically as they were designed to do but cooling systems associated with two sites had been damaged. 

Three reactor sites are adjacent to the earthquake epicentre and two were in the direct path of the tsunami.  The Fukushima-Daiichi plant belonging to Tokyo Electric Power Company was particularly hard hit.  It lost all grid connections, providing electricity, and its backup power plant was seriously damaged. 

Read more: The Fukushima Nuclear Crisis

Terms of Use

Terms of Use                                                                    Copyright