Who is Online

We have 234 guests and no members online

Replication

The DNA molecular structure resembles a zip fastener, where each tooth can be any of four molecular bases.  The bases G-C and A-T are each small organic molecules that at one point are covalently bound to a triphosphate (containing three phosphorous atoms) and a sugar group that binds them in a ribbon.  At their free end Guanine is attracted to Cytosine, with triple hydrogen bonds, and Adenine is attracted to Thymine, with double hydrogen bonds. 

In the following notation: black = Carbon;  blue = Nitrogen;  red = Oxygen; white = Hydrogen.   Bars joining them indicate a covalent bond, an electron shared between the atoms.  A double bar indicates two shared electrons.   

 

Cytosine  Cytosine (C4H5N3O) has a shape that attracts (fits)  Guanine Guanine (C5H5N5O) 


but not  Thymine Thymine (C5H6N2O2)  or  Adenine Adenine (C5H5N5), that attract (fit) each other.

 

Each of these bases is bound to a ribbon of  sugar molecules and at its other end lightly bonds to a matching base on the other half of the 'zipper' such that when it is 'unzipped' each attracts its opposite number (like magnets attracting the opposite pole) thus recreating a new matching half in the same sequence.

 

DNA replication.
DNA replication. 

 

This unzipping and reforming is called self-replication. It is going on continuously in all living things as new cells are created to replace those that die. In an adult human around three quarters of a million of our cells divide every second.  This cell division is the process we call organic life and may continue (usually briefly) after we are legally (brain) dead.

Other chemical mechanisms within the cell translate the genetic information stored in the DNA sequence to manufacture the proteins from which new cells are built and differentiate themselves, organising to become our various organs and to thus arrange themselves to form a human; and not a gorilla or a crocodile or a kola or a rose or a cabbage. The human genome project had now identified 32,185 human genes.

Accurate reproduction is very important to the viability of an organism.  Just as: 'WOLF' does not have the same meaning as 'FOWL' the location and order of sequence G-A-T-C within a particular DNA string (chromosome) will result in a different outcome to the sequence C-A-G-T .   And this difference will influence cell structure and purpose:   'The wolf eats the fowl' has a totally different meaning to: 'The fowl eats the wolf'.

This method of storing and reproducing instructions and data is twice as efficient as the binary method we presently use in electronic devices.  For example the binary processor in your computer or reading device requires each character in in each word in this sentence to be encoded in two bytes (each of 8 characters or bits).  In other words 16 ones and zeros are required for every character on this page (eg 'a' = 0000000001100001) and a similar number for each pixel in a simple colour image.  But DNA can encode the same information (sufficient for every unique character and symbol in every language in the world) in just eight characters.

There are a fraction over 3 billion characters in the human genome (3,079,843,747 base pairs).  In computer terms this is equivalent to about three quarters of a gigabyte of information storage. The same data is stored in the nucleus of each of our cells.  This is in nuclear DNA, before taking into account separate, but smaller, storage in each of the mitochondria (see below). 

A 'gig' isn't much you might say (less than $1's worth) but the actual data storage density is in excess of anything offered by our present electronic technology.  Cells are a lot smaller than the chip in a memory stick - there around a billion cells per cubic centimetre in hard tissue.

This also points to another reality.  Had not this replication chemistry been available, and the conditions for the reactions been just right, life could not have occurred in its earthly form. 

Life relying on another replication method that was say binary would be at a disadvantage and would have to use different replication mechanisms.  If there was a chemistry, at different temperatures and chemical concentrations, allowing say six base pairs it would be different again.  We and our cousins (the other animals, plants and other organisms) that are all descended from the original replicating cell (LUCA - see above) are here because the conditions on Earth were and are just right for our kind of life to prosper.

Elsewhere in the universe it may be different.

 

No comments

Travel

Romania

 

 

In October 2016 we flew from southern England to Romania.

Romania is a big country by European standards and not one to see by public transport if time is limited.  So to travel beyond Bucharest we hired a car and drove northwest to Brașov and on to Sighisiora, before looping southwest to Sibiu (European capital of culture 2007) and southeast through the Transylvanian Alps to Curtea de Arges on our way back to Bucharest. 

Driving in Romania was interesting.  There are some quite good motorways once out of the suburbs of Bucharest, where traffic lights are interminable trams rumble noisily, trolley-busses stop and start and progress can be slow.  In the countryside road surfaces are variable and the roads mostly narrow. This does not slow the locals who seem to ignore speed limits making it necessary to keep up to avoid holding up traffic. 

Read more: Romania

Fiction, Recollections & News

Les Misérables - The Musical

 

The musical Les Misérables has returned to Sydney.   By now we have both seen several versions.    

But we agreed that this new version is exceptional, with several quite spectacular staging innovations and an excellent cast of singers with perhaps one exception who was nevertheless very good.

Despite an audience that was obviously very familiar with the material (if I'm to judge by the not so sotto voce anticipatory comments from the woman next to us) the production managed to evoke the required tears and laughter in the appropriate places.  The packed theatre was clearly delighted and, opera style, the audience shouted approval at and applauded several of the vocal performances, some were moved to a standing ovation at the end.

 

 

Read more: Les Misérables - The Musical

Opinions and Philosophy

Electricity Pricing

 

 August 2012 (chapters added since)

 

 

 

Introduction

 

The present government interventions in electricity markets, intended to move the industry from coal to renewable energy sources, are responsible for most of the rapidly rising cost of electricity in Australia.  These interventions have introduced unanticipated distortions and inefficiencies in the way that electricity is delivered.

Industry experts point to looming problems in supply and even higher price increases.

A 'root and branch' review of these mechanisms is urgently required to prevent ever increasing prices and to prevent further potentially crippling distortions.

Read more: Electricity Pricing

Terms of Use

Terms of Use                                                                    Copyright